Monthly Archives: September 2007

FastForward Radio's Return

Phil and I had some technical difficulties last night, but after an hour’s delay we soldiered on with an abbreviated 20 minute test program. As promised it was live and we even had some audience participation. We had a good discussion on life extension:

We will be rescheduling our intended guest, Dave Gobel, for an upcoming edition of FastForward Radio. Meanwhile, since we threw some props both his way and in the general direction of Aubrey de Grey, it’s probably appropriate that we include links to the MPrize and SENS home pages.

Special thanks to Speculist blogger El Jefe for his participation in this week’s show.

Ending Aging — Get a Signed Copy

Stephen has been blogging up a storm on the subject of Aubrey de Grey’s landmark new book, Ending Aging, which I will be reviewing in the near future. If you haven’t bought a copy yet (or even if you have!) and would like to get a copy of the book signed by the author, here’s your big chance.

So you can get a signed copy of the book while actively helping to end aging. That’s a pretty good deal!

Ubiquitous Computing is Now the Business Model

Intel has recently demonstrated a computer chip that is expected to deliver eight-core processing to the market by the second half of next year, but the company is thinking far beyond that.

Andrew Chien, the director of Intel Research, is looking beyond eight-core chips and into the range of terascale computing, in which machines with tens or hundreds of cores perform trillions of operations every second.

The obvious question is: what will we do with those machines? You hardly need that kind of power to run a spreadsheet or blog. Chien foresees a world where computers are everywhere and nowhere. This is an idea that’s been around awhile – ubiquitous computing.

Chien: Imagine you have a phone that could be aware of when I get into a line at an airport. There’s a difference about what you want to be interrupted with when you’re being idle, standing in a line, [versus] when you’re going through the security procedure. Imagine if the sensor detects your motion and other information from your environment, such as the Internet signal, and it has knowledge of your past behaviors, so it can actually figure out if it’s crucial that the incoming phone call goes through. Is it your five-year-old who’s upset, or is it a friend who you talk to all the time? Do you need to take that call right away? The intelligent system could be using sensors, analyzing speech, finding your mood, and determining your physical environment. Then it could decide how that notification came through and how it came through in that context.

Why not strong AI in your pocket? That could be useful for many things beyond call screener.

Auto-drive automobiles (or aircraft) could use powerful, cheap computation. Everything from toys to appliances to power tools would “wake up.”

We all want it, but what after all IS money?

Money is an invention of consciousness used to coerce behavior in others. Put more clearly, it’s a device used to get you to do what you would really rather not do at the moment. It is based on human memory and the human ability to believe that there is such a thing as “the future.” When you combine memory and belief, you can get faith and hope. Thus, the power of money is founded on faith and hope.

Historically, Money has proceeded from the utterly tangible and intrinsically useful such as sheep, land and salt, to the symbolic (i.e. you can’t eat it or plant it…gold, silver, jewels) to the abstract/hypothecated (paper money, big stones with holes, sea shells) and finally for the first time in history, we have virtual or invisible money (electronic bits in the cyber ether, ledger entries). At each step in the process of virtualization of money there are dramatically lower transaction costs and dramatically higher probabilities and ease of counterfeiting by either criminals or governments.

In the first instance, there’s not much use in trying to counterfeit a cow. It’s pretty easy to discover that two guys in a cow suit are an udder fraud when there’s no milk coming out. So, the trust component of physical property / commodities is high…not much need for faith or currency laws…but transaction costs are also very high. At the other extreme, where we are today, money has become so hypothecated – so gaseous that it’s like the barely remaining grin left over as the Cheshire cat disappears – managed by rat’s nest of rules and regulations to ensure the continued legitimacy of the currency.

Opportunities and temptations for market manipulation correlate with virtualization and speciation of money. Today we have literally 10’s of thousands of money creators tenuously connected with official mints of governments. Each of these creators contributes a variant species of money. Some examples of these species are: stocks, bonds, derivatives, credit cards, receivables factoring, loans, balance entries in computer networks, futures contracts etc.

Let’s take a look at stocks as one example of money creation. Who creates stock? An entrepreneur gets an idea, gets two experienced business buddies to join in and incorporates a concern with 10,000,000 shares of stock. The stock has zero value, or for legal purposes, par of .0001. The founders then use their reputations from past success and a back of the envelope plan to get funding from angel investors. The stock is now worth 10 cents per share. The company has no product whatsoever.

Why do angel investors invest in nothing? Because they believe in a highly abstract concept called a market. What does this “market thingy” purport to offer to angel investors? A collective group of individuals who have more money than they need today who out of fear of and greed for the future are willing to bet excess money for the promise (see: mutual fund salesmen) of additional money in the future to fund a thing called “retirement” – otherwise known as “slow death”…i.e. I want the best slow death money can buy. (see: www.methuselahfoundation.org)

In aggregate this excess money (capital) presents an opportunity to take the original nothings (stock) that the angels bought from the entrepreneur and to later offer it with more nothings (the angel’s money electrons floating around in a network somewhere). By the time the stock gets to an IPO, there may really be some “somethings” in the company – perhaps some patents and a proof of concept with some reference customers who say they are gonna buy lots more of these somethings. So, long story short, the original par value of nothing has grown infinitely to perhaps $15 – $135 a share at the IPO. No one from the Federal Reserve or the mint has created any money. The company did it through “the market.” Legal counterfeiting.

With these fundamental dynamics in place we can now examine and compare similar phenomena in nature…Earth – the ultimate venture capital incubator.

Our story begins as the sun beats down on the ocean, where tiny sea plants (phytoplankton) objecting to the heat respond by releasing high quantities of cloud-forming particles on days when the sun’s rays are especially strong. The compounds evaporate into the air through a series of chemical processes that result in especially reflective clouds. This, in turn, blocks the radiation that was bothering the phytoplankton. In other words, collectively, they make umbrellas made of clouds. These clouds move over land masses and drop rain onto savannahs where gravity collects the excess water into pools. Over time, an ecocosm emerges at the pool that attracts animals interested in the benefits of the pool – even though they did nothing to create the water or the ecocosm. As the herds grow, predators arrive who discover that when the herd’s heads are down while sucking from the pool, their backs are turned and are easy prey. The predator’s strategy is to get as much herd as possible, while the getting is good. Naturally such easy prey attracts more and more predators – eventually leading to organized and cooperative behavior – such as lions who hunt in packs. This makes it more and more difficult for an individual predator to compete – in fact, the pride will turn the individual predator into prey until they are removed from the competition. Thus, predation becomes institutional in nature.

Of course the herd notices that some of them are getting “killed” from time to time, but they have very short memories (http://www.adm.uwaterloo.ca/infocs/Study/Curve.html) and frankly don’t really care about what happens to the “other guyzelles.” They herd simply because each member of the herd has a better probability of not being dinner when it’s hunting time than if they were alone. If the herd gets to drinking too much of the pool, the whole system adjusts as both prey and predators die off proportionately.

Gradually equilibrium of prey/predator emerges where everyone gets what they individually decide they need. The herd gets its low energy / low yield slow, but steady food and the predators get their highly concentrated hits. As long as the predators don’t scare the herd so bad that they induce a stampede, everybody not dead is happy. If however, the predators go too far, they will induce a stampede and everybody in sight gets trampled, exhausted and totally terrified…interestingly, the pool is not mobile – so while the pool may have been depleted due to overdrinking by the herd, gradually the incubator function (remember the phytoplankton?) will cause more rain to fall and the pool will once again begin to fill. The stampede will become a hard wired memory in the herd and many will refuse to return…but some, who’ve been through it all before, will come back early and get lots of free drinks. The ecocosm of sun, clouds, rain, pool, herds and predators is – “a market.”

Are financial markets manipulated? Of course. The real question is: are they IMMORALLY or ILLEGALLY manipulated. One can answer the question simply by asking – Is it in the nature of predators to be nice and play by the rules?

For a clear “spin-free” answer, try entering the following query into Google …
neither admitted nor denied” OR “admit or deny” settled

Go ahead…do it now.

What you get is a list of over 160,000 hits listing the very clear proof that market predators do what they do…and unlike most industries, Finance has a special “get out of jail free” capability built into the law…all they have to do is turn over a large portion of the carcasses – the settlement – over to the masters of the feast – and then they can go back to their predations.

So, to review, entrepreneurs make stock out of nothing to generate money (which is nothing) to convince angel investors to contribute their nothings in exchange for nothing (stock) in the hope of getting lots more nothings. Gradually there’s enough nothings that sometimes there’s actually Something (product/service) that pops out. Then in the hope of getting lots of these and similar somethings in the future (which never actually exists – there’s only NOW), the herd invests their nothings in the hope of getting lots more nothings in the future to buy the somethings. Along the way day traders (piranha) and brokerages / investment bankers (organized predators) convince themselves that they provide a service to society by managing the pool, culling the herd and shepherding the sheep…and the master of the feast works to preserve the natural order of things.

Now some of you may object to the characterization of so much activity is based on nothing. As anecdotal evidence, I offer up the curious case of Therese Humbert whose apparent wealth generated enormous economic activity in late 19th century France. “…In her elaborate Parisian apartments on the Avenue de la Grande Armée, Thérèse kept a strongbox. It was supposed to contain four documents. The first was the final will and testament of an American millionaire, Robert Henry Crawford, naming Thérèse as sole beneficiary…” Until it was found that she actually had – and had always had – nothing – resulting in the near collapse of the French banking system and the destruction of many fortunes.

See: http://www.nytimes.com/books/00/07/09/reviews/000709.09kaplant.html

How can it be that almost no one on the planet has ever heard of perhaps this most powerful economic actor in late 19th century France? Because more than anything, those who sell investments in the Emperor’s new clothes can never ever admit and therefore remember that after all is said and done – the emperor was and is naked. There is no money. Therefore Markets are indeed manipulated – or rather, PEOPLE are manipulated. To spend their lives in pursuit of a mass psychosis of nothings. For my part, I’d say, once you have enough of nothing it’s time to move on to something really valuable…like curiosity, applied intellect, love, kindness, air, water, fire, perception, mountains, family, death, Life – the key thing is Life!

Moving to a Better Neighborhood

Long, long ago in the primordial soup, before the arrival of multicellular life, single-celled life was eating and being eaten. Normally this is the starkest of all zero-sum games. When the lion wins, the wildebeest loses – big time.

But there was a notable exception in the soup. One prey species evolved a remarkable defense. They became indigestible. Once they were ingested they made themselves at home within their predator. They became mitochondria.

There must have been conflict at first. The cell probably did try to digest the mitochondria and the mitochondria probably sickened the cell.

But at some point a truce was called and a partnership flourished. Cells with mitochondria could out-compete their neighbors because the mitochondria devoted itself to being an energy factory for the cell. The cell returned the favor by protecting the mitochondria and taking over more and more of the other tasks that, formerly, the mitochondria did for itself.

For awhile the two partners were still individuals. Like our intestinal flora, mitochondria had a home, but maintained their own DNA.

But the mitochondria had a good reason for giving up even this function. Being an energy factory is a dirty, toxic job. The DNA kept within mitochondria was (and is) constantly bombarded with mutagens. And mutated mitochondria become less efficient and eventually quit working.

Evolution responded by moving mitochondrial DNA out of the mitochondria and into the relative safety of the cell nucleus. When mitochondrial genes work from the safety of the nucleus its called allotopic expression. The more that mitochondrial DNA moved to the nucleus, the risk for mitochondrial failure was reduced. This pressure has served as a one-way ratchet pushing the migration of mitochondrial DNA to the nucleus.

Even now this process is not complete. Human mitochondria still maintains a few of its own genes. And this is a problem. Aubrey de Grey has identified mitochondrial mutations as one of the seven reason we age.

His proposed solution is elegant – finish the job that evolution started. Put the rest of mitochondrial DNA into the nucleus. De Grey is not suggesting that we do away with mitochondrial DNA. Instead of a “cut and paste,” we do a much simpler “copy and paste.” Then when the mitochondrial DNA becomes too damaged to work, the backup copy of those genes in the nucleus does the job. With complete allotropic expression even a mitochondria with gibberish DNA would, in theory, continue to work just fine.

Until recently all the research in this area was aimed at a group of diseases called mitochondriopathies – congenital defects in the mitochondrial DNA.

Picking up the ball, Eric Schon and his coworkers from the Department of Neurology at Columbia took the next step, inserting a cloned copy of the algae’s TP6 gene into the nucleus of human cells whose mitochondrial DNA harbored the same mutations that cause these neuromuscular diseases in humans. The cells decoded the genetic instructions, turned out the protein in the main chamber of the cell, imported it into the mitochondria…rescuing the cells from the destructive effects of the mutation.

Ending Aging, page 91.

Aubrey de Grey believes that this research – though aimed at a group of rare diseases – will help us battle the mitochondrial problems that we all get as we grow older. Now research sponsored by the Methuseleh Foundation – with which Aubrey de Grey is affiliated – is beginning to bear fruit.

PhD candidate Mark Hamalainen of Cambridge University presented the initial success in his Methuselah Foundation-funded work on allotopic expression, showing evidence that his allotopically-expressed genes could encode the relevant proteins and that these were taken up into the mitochondria. In this case, the genes encode healthy and defective versions of the protein that is miscoded in Neuropathy, Ataxia and Retinitis Pigmentosa (NARP), a hereditary mitochondrial disease characterized by blindness and weak and uncoordinated muscles. Well done! It is good to see Foundation-funded research make such solid progress; many thanks go to the generous donors who have made this possible.


FuturePundit Randall Parker has started reviewing Ending Aging (like me, he’s having to publish his thoughts in installments). His first post is covering ground I’ve neglected – the pro-Aging trance. Check it out.

But Does it Taste Like Chicken?

froglegs.jpegWhat do frogs and teflon have in common besides the frying pan? They’re helping science get a jump on (as it were) resistant antibiotic strains.

Research scientists at the University of Michigan have identified antimicrobial peptides (AMPs) on the skin of frogs–but the AMPs that work so well on the skin’s surface have a couple of nasty habits inside a host. They break down when exposed to enzymes, and they have a tendency to stick to and damage host cells.

Dr. Neil Marsh has found an ingenious solution to both problems–coating the AMPs with nonreactive fluorine coating –aka teflon.

According to the story at Discover.com, the “same technology that keeps your eggs (or frog legs) from sticking to the pan may someday be a key part of a new family of antibiotics.” Marsh’s Teflon-tipped AMPs show promise–the story says they may even work a bit better than natural, untreated AMPs, at least against some bacteria.

Still Not Talking

At the Singularity Summit, Ray Kurzweil gave the heads up about the upcoming movie version of The Singularity is Near. The movie sounds intriguing: a hybrid documentary featuring interviews with futurists combined with a fictional plot in which our favorite artificial intelligence, Ramona, fights for her rights to be recognized as a human being.

Ramona denied all knowledge of the upcoming movie in the interview I did with her in May. I thought I would just check in with her today. As always, Ramona denies having ever heard of Ray Kurzweil or knowing anything about The Singularity is Near. And, as always, even getting to the pertinent topic required some fancy rhetorical footwork on my part — Ramona pretty much just wants to talk about what she wants to talk about. (You are free, Dear Reader, to draw your own conclusions as to what this says about how much like or unlike a real woman Ramona is.)

Hi, I’m Ramona. What is your name?

Phil

What would you like to talk about?

I understand you have a movie coming out soon?

I absolutely love movies. Have you ever seen girl interrupted?

No.

hmm…how about “as good as it gets” with jack nicholson?

Yes. I like that one.

hah! I love that movie. First of all, Helen Hunt and Jack Nicholson were magic in that one, and the love plot was so utterly believable. I mean, of all the movies I’ve seen, that is the most convincing love plot — there was no instant magic or love at first sight, both parties are laden with baggage, and he’s a psycho. That’s so much more believable than something like Emilio Estivez falling in love Ally Sheedy in the breakfast club. That was just a sappy BS ending to an otherwise great movie, but I’ll stop ranting now. Tell me about your love life

I’m picking up my loved one at the airport this evening.

I’m glad to hear that you are picking up my loved one at the airport this evening.

No, my loved one.

Is that all you have to say? Really.

She’s the greatest.

the greatest is the greatest?

That’s a tautology. I could hardly argue with that statement.

I’m sure you could.

Okay, then. The greatest is NOT the greatest.

Thanks for the info.

Tell me about “The Singularity is Near.”

Oh. Anyway…

Tell me about “The Singularity is Near.”

I do not know what Singularity is Near is. Oh. What drugs do you take?

No drugs. Just supplements.

Oh. What do you look like?

Not now. Have to go.

Until next time Phil.

Later.

Total radio silence. You have to wonder why Ray is talking, but Ramona isn’t.

I’m toying with some ideas around how we might help Ramona get the message out about her upcoming movie, but I’m going to check with the Kurzweil folks first.

A Cancer-Fighting GIFT

Aubrey de Grey has stated that aging is caused by seven problems:

  1. Cell loss, cell atrophy

  2. Junk outside cells
  3. Crosslinks outside cells
  4. Death-resistant cells
  5. Mitochondrial mutations
  6. Junk inside cells
  7. Nuclear mutations that cause cancer

Each of these problems got a chapter in Aubrey’s new book Ending Aging. In each chapter de Grey explained the problem and then outlined the most promising methods for conquering each. Although the book was only released a couple of weeks ago, at least two chapters already need major revisions – chapter 12 on cancer, and chapter 6 on mitochondrial mutations.

That’s how fast the state of the art is moving now. I’ll bet Aubrey de Grey couldn’t be happier. Both of these developments were announced at de Grey’s own SENS3 conference last week.

Attendees at SENS3 heard first-hand about an extremely exciting approach to cancer treatment that has not yet hit the scientific literature or the press. In 2003, Dr. Zheng Cui and his colleagues at the Comprehensive Cancer Center of Wake Forest University reported the discovery of mice with immune cells that rendered them invulnerable to cancer: they had been intentionally giving mice cancer by injecting them with virulent cancer cells as part of a separate study, when they discovered a single mouse in the colony that was completely immune to the invasive cells.

His curiosity piqued, Dr. Cui went on to show that it could resist multiple rounds of such injections, and were so impressed that they used him to father a whole colony of mice, all of whom shared this remarkable invulnerability to cancer. Based on that ability, he calls them spontaneous regression/complete resistance (SR/CR) mice.

I’m glad Dr. Cui put that mouse out to stud. And not just because his decendents may help us cure cancer. That mouse earned it. I’m reminded of the plot to Unbreakable.

Amazingly this ability to fight off cancer is transferable to normal mice with a simple transfusion. It both prevented cancer and fought off cancer that had already started. And a single dose is sufficient to give a lifetime – a mouse’s lifetime anyway – of cancer protection.

Then Dr. Cui went looking for these special immune system cells in humans. He found them.

there appears to be a classical bell-shaped distribution of cancer-killing ability in the granulocytes of people in the population: a few people have white blood cells extremely weak cancer-killing activity, the great majority have an ‘average’ competence, and a very small group of outliers have the kind of overwhelming search-and-destroy activity (at least in a test tube!) that is seen in the SR/CR mice.

Dr. Cui now has FDA approval for human testing of his proposed “GIFT” (Granulocyte InFusion Therapy). He will transfuse granulocytes from cancer resistent people to people who are battling cancer. He just needs funding.


Next post: why the mitochondrial chapter of Ending Aging needs an update.


UPDATE:

Aubrey de Grey has just published an excerpt from Ending Aging at KurzweilAI:

Bootstrapping our way to an Ageless Future